HIV is found throughout all the tissues of the body but is transmitted through the body fluids of an infected person (semen, vaginal fluids, blood, and breast milk).
In this article, we explain HIV and AIDS, their symptoms, causes, and treatments.Overview
HIV is a virus that attacks immune cells called CD-4 cells, which are a subset of T cells. AIDS is the syndrome, which may or may not appear in the advanced stage of HIV infection.
HIV is a virus.
AIDS is a medical condition.
HIV infection can cause AIDS to develop. However, it is possible to contract HIV without developing AIDS. Without treatment, HIV can progress and, eventually, it will develop into AIDS in the vast majority of cases.Causes
HIV can be passed from one person to another through blood-to-blood and sexual contact.
HIV is a retrovirus that infects the vital organs and cells of the human immune system.
The virus progresses in the absence of antiretroviral therapy (ART) - a drug therapy that slows or prevents the virus from developing.
The rate of virus progression varies widely between individuals and depends on many factors.
These factors include the age of the individual, the body's ability to defend against HIV, access to healthcare, the presence of other infections, the individual's genetic inheritance, resistance to certain strains of HIV, and more.
How is HIV transmitted?
Sexual transmission — it can happen when there is contact with infected sexual fluids (rectal, genital, or oral mucous membranes). This can happen while having sex without a condom, including vaginal, oral, and anal sex, or sharing sex toys with someone who is HIV-positive.
Perinatal transmission — a mother can transmit HIV to her child during childbirth, pregnancy, and also through breastfeeding.
Blood transmission — the risk of transmitting HIV through blood transfusion is extremely low in developed countries, thanks to meticulous screening and precautions. However, among people who inject drugs, sharing and reusing syringes contaminated with HIV-infected blood is extremely hazardous.Symptoms
For the most part, the later symptoms of HIV infection are the result of infections caused by bacteria, viruses, fungi, and/or parasites.
These conditions do not normally develop in individuals with healthy immune systems, which protect the body against infection.
Early symptoms of HIV infection
Some people with HIV infection have no symptoms until several months or even years after contracting the virus. However, around 80 percent may develop symptoms similar to flu 2–6 weeks after catching the virus. This is called acute retroviral syndrome.
The symptoms of early HIV infection may include:
- joint pain
- muscle aches
- sore throat
- sweats (particularly at night)
- enlarged glands
- a red rash
- unintentional weight loss
It is important to remember that these symptoms appear when the body is fighting off many types of viruses, not just HIV. However, if you have several of these symptoms and believe you could have been at risk of contracting HIV in the last few weeks, you should take a test.
In many cases, after the initial symptoms disappear, there will not be any further symptoms for many years.
During this time, the virus carries on developing and damaging the immune system and organs. Without medication that stops HIV replicating, this process of slow immune depletion can continue, typically for an average of 10 years. The person living with HIV often experiences no symptoms, feels well, and appears healthy.
For people who are taking antiretrovirals and are rigidly compliant, this phase can be interrupted, with complete viral suppression. Effective antiretrovirals arrest on-going damage to the immune system.
Late-stage HIV infection
If left untreated, HIV weakens the ability to fight infection. The person becomes vulnerable to serious illnesses. This stage is known as AIDS or stage 3 HIV.
Symptoms of late-stage HIV infection may include:
- blurred vision
- diarrhea, which is usually persistent or chronic
- dry cough
- fever of above 100 °F (37 °C) lasting for weeks
- night sweats
- permanent tiredness
- shortness of breath (dyspnea)
- swollen glands lasting for weeks
- unintentional weight loss
- white spots on the tongue or mouth
During late-stage HIV infection, the risk of developing a life-threatening illness is much greater. Serious conditions may be controlled, avoided, and/or treated with other medications, alongside HIV treatment.
HIV and AIDS myths and facts
There are many misconceptions about HIV and AIDS. The virus CANNOT be transmitted from:
- shaking hands
- casual kissing
- touching unbroken skin
- using the same toilet
- sharing towels
- sharing cutlery
- mouth-to-mouth resuscitation
- or other forms of "casual contact"
The CDC (Centers for Disease Control and Prevention) estimates that about 1 in every 8 HIV-positive Americans is unaware of their HIV status.
HIV blood tests and results
Diagnosis is made through a blood test that screens specifically for the virus. If HIV has been found, the test result is "positive." The blood is re-tested several times before a positive result is given.
If a person has been exposed to the virus, it is crucial that they get tested as soon as possible. The earlier HIV is detected, the more likely the treatment will be successful. A home testing kit can be used as well.
After infection with HIV, it can take from 3 weeks to 6 months for the virus to show up in testing. Re-testing may be necessary. If the moment an individual was most at risk of infection was within the last 6 months, they can have the test immediately. However, the provider will urge that another test is carried out within a few weeks.Treatment
The red ribbon is the worldwide symbol of support and awareness for people living with HIV.
There is currently no cure for HIV or AIDS. Treatments can stop the progression of the condition and allow most people living with HIV the opportunity to live a long and relatively healthy life.
Earlier HIV antiretroviral treatment is crucial — it improves quality of life, extends life expectancy, and reduces the risk of transmission, according to the World Health Organization's guidelines issued in June 2013.
Currently, there is no vaccine or cure for HIV, but treatments have evolved which are much more effective and better tolerated; they can improve patients' general health and quality of life considerably, in as little as one pill per day.
It is now established that, given the right treatment, someone living with HIV can reduce his or her viral load to such a degree that it is no longer detectable. After assessing a number of large studies, the CDC concluded that individuals who have no detectable viral load "have effectively no risk of sexually transmitting the virus to an HIV-negative partner."
This is referred to as undetectable = untransmittable (U=U).
Emergency HIV pills (post-exposure prophylaxis)
If an individual believes they have been exposed to the virus within the last 72 hours (3 days), anti-HIV medications, called PEP (post-exposure prophylaxis) may stop infection. The treatment should be taken as soon as possible after contact with the virus.
PEP is a treatment lasting 4 weeks, a total of 28 days. Monitoring for HIV will be continued after completion of the treatment.
HIV is treated with antiretrovirals (ARVs). The treatment fights the HIV infection and slows down the spread of the virus in the body. Generally, people living with HIV take a combination of medications called HAART (highly active antiretroviral therapy) or cART (combination antiretroviral therapy).
There are a number of subgroups of antiretrovirals; these include:
Protease is an enzyme that HIV needs to replicate. As the name suggests, protease inhibitors bind to the enzyme and inhibit its action, preventing HIV from making copies of itself. These include atazanavir/cobicistat (Evotaz), lopinavir/ritonavir (Kaletra), and darunavir/cobicistat (Prezcobix).
HIV needs the integrase enzyme to infect T cells. This drug prevents that step. Integrase inhibitors are often used in the first line of treatment because they are effective for many people, and cause minimal side effects. Integrase inhibitors include elvitegravir (Vitekta), dolutegravir (Tivicay), and raltegravir (Isentress)
Nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs)
These drugs, also referred to as "nukes," interfere with HIV as it tries to replicate and make more copies of itself. NRTIs include abacavir (Ziagen), lamivudine/zidovudine (Combivir), and emtricitabine (Emtriva)
Non-nucleoside reverse transcriptase inhibitors (NNRTIs)
NNRTIs work in a similar way to NRTIs, making it more difficult for HIV to replicate.
Chemokine co-receptor antagonists
Also known as CCRF, these drugs block HIV from entering cells. They are rarely used in America because other drugs are more effective.
Entry inhibitors prevent HIV from entering T cells. Without access to these cells, HIV cannot replicate. As with chemokine co-receptor antagonists, they are rarely used in the United States.
A combination of these drugs will be used; the exact mix of drugs is adapted to each individual. HIV treatment is usually permanent and lifelong. HIV treatment is based on routine dosage. Pills must be taken on a regular schedule, every time. Each class of ARVs has different side effects, but some possible common side effects include:
- skin rashes
Complementary or alternative medicine
Although widely used, alternative or complementary medications, such as herbal ones, have not been proven to be effective. According to some limited studies, mineral or vitamin supplements may provide some benefits in overall health. It is important to discuss these options with a healthcare provider because some of these options, even vitamin supplements, may interact with ARVs.
To prevent contracting HIV, healthcare professionals advise precautions related to:
Condomless sex - having sex without a condom can put a person at risk of contracting HIV and other sexually transmitted infections (STIs). HIV can be transmitted by having sex without a condom (vaginal, oral, and/or anal sex). It can also be transmitted by sharing sex toys with someone infected with HIV. Condoms should be used with every sexual act.
Drug injection and needle sharing - intravenous drug use is an important factor in HIV transmission in developed countries. Sharing needles can expose users to HIV and other viruses, such as hepatitis C. Strategies such as needle-exchange programs are used to reduce the infections caused by drug abuse. If someone needs to use a needle, it must be a clean, unused, unshared needle.
Body fluid exposure - exposure to HIV can be controlled by employing precautions to reduce the risk of exposure to contaminated blood. Healthcare workers should use barriers (gloves, masks, protective eyewear, shields, and gowns) in the appropriate circumstances. Frequent and thorough washing of the skin immediately after coming into contact with blood or other bodily fluids can reduce the chance of infection.
Pregnancy - some ARVs can harm the unborn child. But an effective treatment plan can prevent HIV transmission from mother to baby. Precautions have to be taken to protect the baby's health. Delivery through cesarean section may be necessary.
HIV-infected mothers can pass the virus through their breast milk. However, if the mother is taking the correct medications, the risk of transmitting the virus is greatly reduced. It is important for a new mother to discuss the options with a healthcare provider.
Education - teaching people about known risk factors is vital.Management
Adherence - HIV treatment is effective if medication is taken as prescribed. Missing even a few doses may jeopardize the treatment. A daily, methodical routine should be programmed to fit the treatment plan around the individual's lifestyle and schedule. A treatment plan for one person may not be the same treatment plan for another. "Adherence" is sometimes known as "compliance".
General Health - it is crucial to take medication correctly and take steps to avoid illness. People living with HIV should seek to improve their general health by regularly exercising, eating healthfully, and not smoking.
Additional precautions - people living with AIDS should be extra cautious to prevent exposure to infection. They should be careful around animals and avoid coming into contact with cat litter, animal feces, and birds, too. Meticulous and regular washing of hands is recommended. These precautions are not as necessary while taking therapy.
Long-term condition - HIV is a lasting condition, so it is important to be in regular contact with the healthcare team. The treatment plan will be regularly reviewed.
Psychological - common misconceptions about AIDS and HIV are diminishing. However, the stigma of the condition persists in many parts of the world. People who are living with HIV may feel excluded, rejected, discriminated, and isolated.
Being diagnosed with HIV can be very distressing, and feelings of anxiety or depression are common. If you feel anxious or have symptoms of depression, seek medical help immediately.
HIV/AIDS is an epidemic that effects both men and women of all ages. It has an impact on many people’s lives either by themselves being infected, knowing someone who is infected, or being a health care worker.
HIV is a virus that attacks the body’s immune system. It also effects the blood cells (lymphocytes) and cells of the organs (bone marrow, spleen, liver, and lymph glands). It effects the lungs, central nervous system and gastrointestinal system.
People begin with having the HIV virus. An HIV infected person is likely to stay fit and well for a long time. In time, however the infected person develops rare illnesses or cancers because their immune system is weakened. When this happens, the person now has AIDS. Some people live for several years once they have AIDS, but it is always fatal.
HIV is diagnosed with a blood test known as an HIV antibody test or HIV test. If the test shows that HIV is present, the person is referred to as HIV positive. It may take up to 6 months after contact to show up.
The number of women with HIV and AIDS in the United States is steadily rising. From 1985 to 1996, the proportion of reported US AIDS cases occurring among women increased from 7-20% (Women and AIDS). An analysis from the National Cancer Institute estimates that between 107,000 and 150,000 women on the U.S. are living with HIV infection (many of whom have not developed AIDS (Women and AIDS)
AIDS presents a great worry for women. It is the third leading cause of death among women ages 25 to 44 and the leading cause of death among African-American women of the same age group. (Women and AIDS)
Although AIDS cases are reported in all 50 states, the highest rates in 1996 were in New York, New Jersey, Florida, Maryland and Delaware (Women and AIDS)
HIV may not produce any initial symptoms. However, as this disease progresses, symptoms begin to appear. Among them are: fatigue, unexplained weight loss, night sweats, fever, diarrhea, recurrent respiratory and skin infections, swollen lymph glands throughout the body, genital changes, enlarged spleen and mouth sores. Vaginal yeast infections, common and easily treated in most women, are harder to treat in HIV infected women. Bacterial vaginosis and common STDs such as gonorrhea, chlamydia trichomoniasis, and pelvic inflammatory disease are more common and aggressive in HIV-infected women. Menstrual irregularities, headache, sore muscles and joints, stomach ache and skin rash. Many people mistake some symptoms for the flu. AIDS symptoms also include weight loss, brain tumors and other health problems.
In order to become infected, a person must get a sufficient amount of HIV into their bloodstream. HIV/AIDS is spread though semen, vaginal fluids, menstrual fluids and breast milk. HIV/AIDS is not spread though saliva, sweat glands or urine.
A woman can become infected if she has unprotected penetrative sex vaginal or anal, with a man who has HIV. A woman having vaginal sex with a man who has HIV is 2-3 times more likely to become infected than a man would be if he had vaginal sex with an infected woman (HIV and AIDS).
AIDS is also spread though sharing contaminated needles for IV drug use, transfusions of blood or blood products from a person with AIDS and children born to an infected mother.
Many women in the U.S. have poor access to health care. In addition, women may not perceive themselves to be at risk for HIV infection. Because of this, symptoms that serve as a warning sign of HIV infection may go unheeded (Women and AIDS). Early diagnosis of HIV infection allows women to take full advantage of drug therapies for opportunistic infections, which can forestall the development of AIDS related symptoms and prolong life in HIV-infected people. (Women and AIDS)
There are different theories as to the origin of AIDS. AIDS was identified as a new disease in 1981 (Sowadsky). HIV is believed to have originated in Africa sometime between the late 1940s and the early 1950s from the monkey AIDS virus SIV, (Simian Immudificiency virus) (Sowadsky). The two viruses are very similar and are transmitted the same way. However HIV only causes AIDS in humans, and SIV only causes AIDS in monkeys. The SIV virus is found in blood. HIV must have entered humans via monkey blood. This could’ve happened by humans drinking monkey blood, eating raw monkeys or another direct exposure of monkey blood into humans (Sowadsky).
There are some theories that AIDS is a man-made virus created by the government. According to my references, there is no evidence of this. This issue, however, will probably never be resolved.
Many women are living with the HIV virus. As well as coping with their own virus, they are also trying to take care of family responsibilities. They may also have financial and treatment concerns, as well as a concern whether to have children.
Many women have great concerns whether to have children and the risk of their children of becoming infected. The chance of the virus being transmitted from mother to baby is about one in seven. Most perinatal transmission occurs late in pregnancy or during birth. Some scientists believe HIV may be transmitted when maternal blood enters the fetal circulation or by mucosal exposure to the virus during labor and delivery (Women and AIDS). Other factors that may increase the risk of perinatal transmission are maternal drug use, severe inflammation of fetal membranes, or a prolonged period between membrane rupture and delivery (Women and AIDS).
There are many things that we can do to try to prevent the spread of AIDS. We can avoid sexual contact with infected people and known IV drug users. Condoms should always be used. Avoiding unscreened blood product and un-steralized IV drug needles can also reduce the risk.
“HIV and AIDS: Information for Women.” International Association of Physicians in AIDS Care. 21 March 1999.
“Women and HIV” Health Square. 21 March 1999.
Sowadsky, Rick . “The Origin of the AIDS Virus” The Body: An AIDS and HIV Information Resource. 21 March 1999.
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